MC-SN38

• Target:

  Drug-Linker Conjugates for ADC

• Related Pathways:

  Antibody-drug Conjugate/ADC Related

• Bioactivity:

  MC-SN38 is a drug-linker conjugate that pairs the potent microtubule-disrupting agent SN38 with a non-cleavable MC linker, designed for use in antibody drug conjugates (ADCs) . SN38, the active metabolite of the Topoisomerase I inhibitor Irinotecan, works by inhibiting DNA synthesis and inducing DNA single-strand breaks.

• Smiles:

  CCc1c2Cn3c(cc4c(COC(=O)[C@@]4(CC)OC(=O)CCCCCN4C(=O)C=CC4=O)c3=O)-c2nc2ccc(O)cc12

• Molecular Formula:

  C32H31N3O8

• Molecular Weight:

  585.6

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1473403-87-0