CL2E-SN38

• Target:

  Drug-Linker Conjugates for ADC

• Related Pathways:

  Antibody-drug Conjugate/ADC Related

• Bioactivity:

  CL2E-SN-38 is a structurally stable and highly releasable antibody-drug conjugate (ADC) incorporating SN-38, the active metabolite of Irinotecan and a potent Topoisomerase I inhibitor [1] from the camptothecins class.

• Smiles:

  O=C1N2C(C=3C(C2)=C(CC)C=4C(N3)=CC=C(OC(N(CCN(C(OCC5=CC=C(NC([C@@H](NC([C@H](CC6=CC=CC=C6)NC(COCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCN7C=C(CNC(=O)C8CCC(CN9C(=O)C=CC9=O)CC8)N=N7)=O)=O)=O)CCCCN)=O)C=C5)=O)C)C)=O)C4)=CC%10=C1COC(=O)[C@@]%10(CC)O

• Molecular Formula:

  C87H116N14O24

• Molecular Weight:

  1741.93

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1639139-65-3