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CDK8-IN-15

CAT: 0931-T88777-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T88777-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2988020-03-5
Target
CDK
Related Pathways
Cell Cycle/Checkpoint
Bioactivity
CDK8-IN-15 (Compound 46) is a potent inhibitor of CDK8, exhibiting an IC50 value of 57 nM. This compound enhances the thermal stability of CDK8 and inhibits NF-κB, while selectively targeting the CDK family and tyrosine kinases. Additionally, it actively counteracts TNF-α-induced psoriasis in vitro and boosts the expression of Foxp3 and IL-10, potentially diminishing inflammatory responses and showing promise for research into psoriasis treatments.
Smiles
O=C(NC=1C=CC(=C(OC)C1)C2=CN=C3NC=CC3=C2)N4CCOCC4
Molecular Formula
C19H20N4O3
Molecular Weight
352.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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