CDK8-IN-15

• Target:

  CDK

• Related Pathways:

  Cell Cycle/Checkpoint

• Bioactivity:

  CDK8-IN-15 (Compound 46) is a potent inhibitor of CDK8, exhibiting an IC50 value of 57 nM. This compound enhances the thermal stability of CDK8 and inhibits NF-?B, while selectively targeting the CDK family and tyrosine kinases. Additionally, it actively counteracts TNF-?-induced psoriasis in vitro and boosts the expression of Foxp3 and IL-10, potentially diminishing inflammatory responses and showing promise for research into psoriasis treatments.

• Smiles:

  O=C (NC=1C=CC (=C (OC) C1) C2=CN=C3NC=CC3=C2) N4CCOCC4

• Molecular Formula:

  C19H20N4O3

• Molecular Weight:

  352.39

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2988020-03-5