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HSD17B13-IN-23

CAT: 0931-T86612-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T86612-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2758802-19-4
Target
Dehydrogenase
Related Pathways
Metabolism
Bioactivity
HSD17B13-IN-23 (compound 18) serves as a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), demonstrating inhibition constants (IC 50) of <0.1 μM and <1 μM when estradiol and Leukotriene B3 act as substrates, respectively. This compound is significant in the management of nonalcoholic fatty liver diseases (NAFLDs), including nonalcoholic steatohepatitis (NASH) [1].
Smiles
C(NCCC(C)(C)C)(=O)C1=C(NC(=O)C2=CC(F)=C(O)C(F)=C2)C=CS1
Molecular Formula
C18H20F2N2O3S
Molecular Weight
382.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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