HSD17B13-IN-7

HSD17B13-IN-7

• CAS Number: 863564-16-3
• UNSPSC Description: HSD17B13-IN-7 (compound 1), a fluorophenol-containing compound, is a potent HSD17B13 inhibitor with IC50s of 0.18 μM and 0.25 μM β-estradiol and Leukotriene B4 as substrates, respectively. HSD17B13-IN-7 is a potent N-methyl-D-aspartate (NMDA) NR2B receptor antagonist. HSD17B13-IN-7 has the potential for non-alcoholic fatty liver disease research[1].
• Target Antigen: 17β-HSD; iGluR
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/hsd17b13-in-7.html
• Solubility: 10 mM in DMSO
• Smiles: FC1=C(O)C=CC(C(NC[C@]2(O)CC[C@H](COC3=CC=CC=C3)CC2)=O)=C1
• Molecular Weight: 373.42
• References & Citations: [1]Shenping Liu, et al. Structural basis of lipid-droplet localization of 17-beta-hydroxysteroid dehydrogenase 13. Nat Commun. 2023 Aug 24;14(1):5158.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported