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HSD17B13-IN-104

CAT: 0931-T211202-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T211202-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3075100-76-1
Target
Dehydrogenase
Related Pathways
Metabolism
Bioactivity
HSD17B13-IN-104 (Compound 32) is an orally active and potent inhibitor of HSD17B13 with high selectivity (IC50=2.5 nM) . It modulates liver lipid metabolism by inhibiting the SREBP-1c/FAS pathway and blocks the enzymatic activity of HSD17B13 to alleviate hepatic lipid accumulation. HSD17B13-IN-104 shows potential for research in metabolic dysfunction-associated fatty liver disease.
Smiles
O=C(C=1SC(=NC1C)C=2C=C(F)C(F)=C(O)C2F)N(CC3=CC=C(Cl)C=C3)C(C)C
Molecular Formula
C21H18ClF3N2O2S
Molecular Weight
454.89
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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