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HAChE-IN-5

CAT: 0931-T82243-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T82243-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Cholinesterase (ChE), Beta Amyloid, GSK-3
Related Pathways
Stem Cells, Neuroscience, PI3K/Akt/mTOR signaling
Bioactivity
HAChE-IN-5 (compound 49) is a dual inhibitor of human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBuChE), showing IC50 values of 0.17 μM for both enzymes. It also potently inhibits glycogen synthase kinase 3 beta (GSK3β) with an IC50 of 0.21 μM. Furthermore, it effectively inhibits tau protein and Aβ1-42 peptide self-aggregation, and can bind the peripheral anionic site (PAS) to prevent amyloid-beta (Aβ) -induced neurotoxicity. hAChE-IN-5's ability to cross the blood-brain barrier (BBB) supports its potential in developing multitargeted anti-Alzheimer's agents [1].
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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