GNE-207

• Target :

  Histone Acetyltransferase|||Epigenetic Reader Domain

• Related Pathways :

  Chromatin/Epigenetic

• Bioactivity :

  GNE-207 is a selective and orally bioavailable inhibitor of the bromodomain of CBP (IC50: 1 nM) . It has a selective index of >2500-fold against BRD4 (1) . GNE-207 displays excellent CBP potency (EC50: 18 nM for MYC expression in MV-4-11 cells) .

• Smiles :

  CNC(=O)c1ccc(cn1)-c1cc2cccc(-c3nn(C4CCOCC4)c4CCN(Cc34)C(C)=O)c2cn1

• Molecular Formula :

  C29H30N6O3

• Molecular Weight :

  510.59

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2158266-58-9