Products for Research Use Only

GNE-207

CAT: 0931-T15399-01Size: 25 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T15399-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
2158266-58-9
Target
Histone Acetyltransferase, Epigenetic Reader Domain
Related Pathways
Chromatin/Epigenetic
Bioactivity
GNE-207 is a selective and orally bioavailable inhibitor of the bromodomain of CBP (IC50: 1 nM) . It has a selective index of >2500-fold against BRD4 (1) . GNE-207 displays excellent CBP potency (EC50: 18 nM for MYC expression in MV-4-11 cells) .
Smiles
CNC(=O)c1ccc(cn1)-c1cc2cccc(-c3nn(C4CCOCC4)c4CCN(Cc34)C(C)=O)c2cn1
Molecular Formula
C29H30N6O3
Molecular Weight
510.59
Shipping Conditions
Ice Packs
Storage Temperature
-20°C