GNE-207

• Target:

  Histone Acetyltransferase|||Epigenetic Reader Domain

• Related Pathways:

  Chromatin/Epigenetic

• Bioactivity:

  GNE-207 is a selective and orally bioavailable inhibitor of the bromodomain of CBP (IC50: 1 nM) . It has a selective index of >2500-fold against BRD4 (1) . GNE-207 displays excellent CBP potency (EC50: 18 nM for MYC expression in MV-4-11 cells) .

• Smiles:

  CNC (=O) c1ccc (cn1) -c1cc2cccc (-c3nn (C4CCOCC4) c4CCN (Cc34) C (C) =O) c2cn1

• Molecular Formula:

  C29H30N6O3

• Molecular Weight:

  510.59

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2158266-58-9