GNE-900

• Target:

  Apoptosis|||Chk

• Related Pathways:

  Cell Cycle/Checkpoint|||Apoptosis

• Purity:

  0.992

• Bioactivity:

  GNE-900 is an ATP-competitive ChK1 inhibitor with selective and oral activity.GNE-900 inhibits ChKl and ChK2 with IC50 values of 0.0011 and 1.5 µM, respectively.GNE-900 enhances DNA damage and induces apoptosis. GNE-900 has antitumor activity.

• Smiles:

  C(#N)C=1C=C2C=3C(NC2=CN1)=NC=C(C3)C4=CC=C(CN5CCCCC5)C=C4

• Molecular Formula:

  C23H21N5

• Molecular Weight:

  367.45

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1200126-26-6