GNE-431

• Target:

  Others|||BTK

• Related Pathways:

  Angiogenesis|||Tyrosine Kinase/Adaptors|||Others

• Bioactivity:

  GNE-431 is a potent, selective and noncovalent Btk inhibitor with IC50 of 3.2 nM. GNE-431 showed excellent potency against the C481R, T474I, and T474M mutants. GNE-431 may provide a treatment option to patients, especially those who have acquired resistance to ibrutinib by mutation of Cys481 or Thr474.

• Smiles:

  O=C1C=2N(C3=C(C2)CCCC3)CCN1C4=C(CO)C(=CC=N4)C=5C=C(NC=6C=C7N(N6)CCN(C)C7)C=8N(N5)C=CN8

• Molecular Formula:

  C30H32N10O2

• Molecular Weight:

  564.64

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1433820-83-7