EGFR mutant-IN-2

CAT: 0931-T86344-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T86344-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2770009-06-6

Target

EGFR

Related Pathways

Tyrosine Kinase/Adaptors, JAK/STAT signaling, Angiogenesis

Bioactivity

EGFR mutant-IN-2 (Compound D51) is an inhibitor of EGFR mutants, specifically targeting EGFR L858R/T790M/C797S and EGFR del19/T790M/C797S mutants with IC50 values of 14 nM and 62 nM, respectively. This compound exhibits favorable pharmacokinetic (PK) parameters, safety properties, in vivo stability, and demonstrates antitumor activity [1].

Smiles

C(F)(F)(F)C=1C(C=2C=3C(N(S(CC)(=O)=O)C2)=CC=CC3)=NC(NC=4C=C5C(=CC4)N(CCN(C)C)C=C5)=NC1

Molecular Formula

C27H27F3N6O2S

Molecular Weight

556.6

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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EGFR mutant-IN-2

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