ALK/EGFR-IN-2

CAT: 0931-T79393-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T79393-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2730432-75-2

Target

ALK, Others

Related Pathways

Others, Tyrosine Kinase/Adaptors, Angiogenesis

Bioactivity

ALK/EGFR-IN-2 is a potent dual inhibitor targeting ALK and EGFR, promoting apoptosis and G0/G1 cell cycle arrest in cancer cells. It effectively suppresses proliferation in H1975, PC9, and Baf3-EML4-ALK cancer cell lines, with IC50s of 0.0034, 0.0065, and 0.0018 μM, respectively [1].

Smiles

N(CCN(C)C)(C)C1=C(NC(C=C)=O)C=C(NC=2N=C(NC3=C(S(CC)=O)C=CC=C3)C(Cl)=CN2)C(OC)=C1

Molecular Formula

C27H34ClN7O3S

Molecular Weight

572.12

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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