EGFR mutant-IN-1

CAT: 0931-T11164-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T11164-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

EGFR

Related Pathways

Angiogenesis, JAK/STAT signaling, Tyrosine Kinase/Adaptors

Bioactivity

EGFR mutant- in-1, A 5-methylpyrimidopyridone derivative are effective selective EGFRL858R/T790M/C797S mutant inhibitors with IC50 of 27.5 nM, which significantly weakened EGFRWT effect.

Smiles

O=C1C(C2=CC=CC(F)=C2Cl)=C(C)C3=CN=C(NC4=CC=C(N5CCN(C)CC5)C(C)=C4)N=C3N1[C@H]6CN(C(CC)=O)CCC6

Molecular Formula

C34H39ClFN7O2

Molecular Weight

632.17

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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EGFR mutant-IN-1

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