EGFR-IN-2

CAT: 0931-T11159-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-T11159-01Size:1 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1643497-70-4

Target

EGFR

Related Pathways

JAK/STAT signaling, Tyrosine Kinase/Adaptors, Angiogenesis

Purity

0.9979

Bioactivity

EGFR-IN-2 is a non-covalent, orally available and mutation-selective EGFR inhibitor for the treatment of non-small cell lung cancer (NSCLC), with high selectivity for resistant single and double mutant T790M with IC50 = 27 nm to 33 nM, and low inhibitory activity for wild-type H292 (IC50 = 218 nM) .

Smiles

[C@@H](CC)(C)N1N=C(C=2C1=CC(NC3=NC(=NC=C3)C4=CN(S(=O)(=O)C5CC5)N=C4)=NC2)N6CC(C(C)(C)O)C6

Molecular Formula

C26H33N9O3S

Molecular Weight

551.66

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Alternative Products

Catalog	Name
HY-100520-01	EGFR-IN-2
HY-128860	Mutated EGFR-IN-2
HY-155005-01	EGFR mutant-IN-2
HY-150905	EGFR ligand-2
HY-158018	EGFR-TK-IN-2
HY-168170	EGFR/VEGFR2-IN-2
MBS5821055	ALK/EGFR-IN-2
MBS5821388	EGFR/CDK2-IN-2
MBS5820510	EGFR/BRAFV600E-IN-2
GTR19239962-01	SOS1/EGFR-IN-2

EGFR-IN-2

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