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EGFR ligand-2

CAT: 0931-T86343-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T86343-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2737283-20-2
Target
EGFR
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling
Bioactivity
EGFR ligand-2 (compound C4) is a covalent EGFR ligand and mutant inhibitor with IC50 values of 21 nM for EGFR L858R and 48 nM for EGFR L858R/T790M. It can be utilized in the synthesis of PROTAC [1].
Smiles
N(C=1N(C=2C(N1)=CN=C(NC3=CC=C(C=C3)N4CCN(C)CC4)N2)[C@@H]5CN(C(C=C)=O)CCC5)C6=CC=CC=C6
Molecular Formula
C30H35N9O
Molecular Weight
537.66
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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