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EGFR ligand-14

CAT: 0804-HY-177379Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-177379Size:1 Each
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Description
EGFR ligand-14 is an EGFR ligand. EGFR ligand-14 can be used for the synthesis of SJF-1521.
CAS Number
1792968-00-3
UNSPSC
12352005
Target
EGFR; Ligands for Target Protein for PROTAC
Related Pathways
JAK/STAT Signaling; PROTAC; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
FC1=CC(COC2=CC=C(NC3=C4C=C(C5=CC=CC=C5)C=CC4=NC=N3)C=C2Cl)=CC=C1
Molecular Formula
C27H19ClFN3O
Molecular Weight
455.91
References & Citations
[1]Burslem GM, et al. The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study. Cell Chem Biol. 2018 Jan 18;25 (1) :67-77.e3.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-phenylquinazolin-4-amine
CAS Number1792968-00-3
PubChem CID118370976
IUPAC NameN-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-phenylquinazolin-4-amine
Molecular FormulaC27H19ClFN3O
Molecular Weight455.9
XLogP7.2
Topological Polar Surface Area47
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count33
Formal Charge0
Complexity606
SMILES
C1=CC=C(C=C1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl
InChI
InChI=1S/C27H19ClFN3O/c28-24-15-22(10-12-26(24)33-16-18-5-4-8-21(29)13-18)32-27-23-14-20(19-6-2-1-3-7-19)9-11-25(23)30-17-31-27/h1-15,17H,16H2,(H,30,31,32)
InChIKey
IDRCRUFPWMCBFF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-phenylquinazolin-4-amine
CAS: 1792968-00-3
CID: 118370976
Formula: C27H19ClFN3O
MW: 455.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight455.9
XLogP37.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass455.1200681
Monoisotopic Mass455.1200681
Topological Polar Surface Area47 Ų
Heavy Atom Count33
Formal Charge0
Complexity606
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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