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Antitumor agent-100

CAT: 0931-T85701-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T85701-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2841750-32-9
Target
PDE, Apoptosis
Related Pathways
Apoptosis, Metabolism
Bioactivity
Antitumor Agent-100 (compound A6) is a molecular gel and apoptosis inducer targeting PDE3A-SLFN12 with an IC50 of 0.3 μM, demonstrating potent antitumor activity. This orally available agent binds to the PDE3A enzyme pocket, recruiting and stabilizing SLFN12 which disrupts protein translation and induces apoptosis [1].
Smiles
ClC1=C2C(NC=3N(C2)CC(=O)N3)=CC=C1C4=CC=C(C)C=C4
Molecular Formula
C17H14ClN3O
Molecular Weight
311.77
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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