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Sulfonadyn-47

CAT: 0931-T83891-01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0931-T83891-01Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Others
Related Pathways
Others
Bioactivity
Sulfonadyn-47 is a dynamin inhibitor that effectively inhibits dynamin GTPase activity with an IC50 of 3.5 μM in cell-free assays. Additionally, it disrupts clathrin-mediated endocytosis in U2OS cells (IC50 = 27.3 μM) and impedes the depolarization-stimulated uptake of the synaptic vesicle endocytosis (SVE) marker FM4-64 in isolated rat brain synaptosomes (IC50 = 12.3 μM) . Significantly, in vivo administration of sulfonadyn-47 at doses of 30 and 60 mg/kg demonstrates anticonvulsant properties in the 6 Hz corneal kindling mouse model of seizures.
Smiles
BrC1=CC=C(/C=C/CNCCCNS(=O)(C2=C(C=CC=C3)C3=CC=C2)=O)C=C1
Molecular Formula
C22H23BrN2O2S
Molecular Weight
459.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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