Sulfonadyn-47

• Target:

  Others

• Related Pathways:

  Others

• Bioactivity:

  Sulfonadyn-47 is a dynamin inhibitor that effectively inhibits dynamin GTPase activity with an IC50 of 3.5 µM in cell-free assays. Additionally, it disrupts clathrin-mediated endocytosis in U2OS cells (IC50 = 27.3 µM) and impedes the depolarization-stimulated uptake of the synaptic vesicle endocytosis (SVE) marker FM4-64 in isolated rat brain synaptosomes (IC50 = 12.3 µM) . Significantly, in vivo administration of sulfonadyn-47 at doses of 30 and 60 mg/kg demonstrates anticonvulsant properties in the 6 Hz corneal kindling mouse model of seizures.

• Smiles:

  BrC1=CC=C(/C=C/CNCCCNS(=O)(C2=C(C=CC=C3)C3=CC=C2)=O)C=C1

• Molecular Formula:

  C22H23BrN2O2S

• Molecular Weight:

  459.4

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C