TRK-IN-24

CAT: 0931-MF-0157404-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0157404-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2937544-01-7
Target
Trk receptor
Related Pathways
Tyrosine Kinase/Adaptors
Bioactivity
TRK-IN-24 (compound 10g) is a selective inhibitor of Trk receptors, effectively targeting TRKA, TRKC, and mutant forms TRKA G595R, TRKA G667C, and TRKA F589L, with corresponding IC50 values of 5.21, 4.51, 6.77, 1.42, and 6.13 nM. It demonstrates antitumor activity in BaF3-CD74-NTRK1 G595R and BaF3-CD74-NTRK1 G667C xenograft models and inhibits the proliferation of Ba/F3 cells expressing single mutants SF, GK, and xDFG, with an IC50 range of 1.43-47.56 nM [1].
Smiles
O=C1C2=NN3C(=CN=C3C=C2)C#CC4=C(C)C(C(NC5=CC(=CC(CN6CCN(C)CC6)=C5)C7CC7)=O)=CC(=C4)OCCCCCCCN1
Molecular Formula
C39H45N7O3
Molecular Weight
659.82
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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