Sirt1/2-IN-2

CAT: 0931-T79563-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T79563-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

670267-73-9

Target

Apoptosis, Sirtuin

Related Pathways

Apoptosis, Chromatin/Epigenetic, DNA Damage/DNA Repair

Bioactivity

Sirt1/2-IN-2 (compound hsa55) is a dual inhibitor, targeting SIRT1 with an IC50 of 1.8 μM and SIRT2 with an IC50 of 2.4 μM. It effectively inhibits p53 deacetylation while enhancing the acetylation of p53 and α-tubulin, promoting apoptosis and exhibiting anti-proliferative effects on human leukemia cell lines [1].

Smiles

N(S(=O)(=O)C1=CC=CC=C1)C=2C3=C(C(O)=C(SC=4NC=NN4)C2)C=CC=C3

Molecular Formula

C18H14N4O3S2

Molecular Weight

398.46

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

N-[4-hydroxy-3-(1H-1,2,4-triazol-5-ylsulfanyl)naphthalen-1-yl]benzenesulfonamide

CAS Number	670267-73-9
PubChem CID	2133777
IUPAC Name	N-[4-hydroxy-3-(1H-1,2,4-triazol-5-ylsulfanyl)naphthalen-1-yl]benzenesulfonamide
Molecular Formula	C18H14N4O3S2
Molecular Weight	398.5
XLogP	3.8
Topological Polar Surface Area	142
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	5
Heavy Atom Count	27
Formal Charge	0
Complexity	594

SMILES

C1=CC=C(C=C1)S(=O)(=O)NC2=CC(=C(C3=CC=CC=C32)O)SC4=NC=NN4

InChI

InChI=1S/C18H14N4O3S2/c23-17-14-9-5-4-8-13(14)15(10-16(17)26-18-19-11-20-21-18)22-27(24,25)12-6-2-1-3-7-12/h1-11,22-23H,(H,19,20,21)

InChIKey

DIHWMXSCKBJTOT-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 670267-73-9

CID: 2133777

Formula: C18H14N4O3S2

MW: 398.5

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	398.5
XLogP3	3.8
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	5
Exact Mass	398.05073267
Monoisotopic Mass	398.05073267
Topological Polar Surface Area	142 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	594
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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T60373-01	SIRT1-IN-2
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T79564-01	Sirt1/2-IN-3
T62240-01	Sirt1/2-IN-1
T74894-01	SIRT1/2/3-IN-1
T23357-01	SIRT1/2 Inhibitor IV
TMAB-01691-01	Anti-SIRT1 Polyclonal Antibody 2
T9648-01	SIRT1-IN-1
T204722-01	SIRT1-IN-4
T24792-01	SIRT1-I5

Alternative Products

Catalog	Name
MBS5821225	Sirt1/2-IN-2
HY-146689-01	SIRT1-IN-2
HY-114906-01	SIRT1/2/3-IN-2
HY-155729	Sirt1/2-IN-4
HY-146013	Sirt1/2-IN-1
HY-155728	Sirt1/2-IN-3
HY-156023-01	SIRT1 activator 2
TBI1514-5MG	Salermide, SIRT1&2 inhibitor
C5522-10	SIRT1/2 Inhibitor IV
MBS5816828	SIRT1/2/3-IN-1

Sirt1/2-IN-2

Chemical Information

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