Sirt1/2-IN-2

CAT: 0931-T79563-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T79563-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

670267-73-9

Target

Apoptosis, Sirtuin

Related Pathways

Apoptosis, Chromatin/Epigenetic, DNA Damage/DNA Repair

Bioactivity

Sirt1/2-IN-2 (compound hsa55) is a dual inhibitor, targeting SIRT1 with an IC50 of 1.8 μM and SIRT2 with an IC50 of 2.4 μM. It effectively inhibits p53 deacetylation while enhancing the acetylation of p53 and α-tubulin, promoting apoptosis and exhibiting anti-proliferative effects on human leukemia cell lines [1].

Smiles

N(S(=O)(=O)C1=CC=CC=C1)C=2C3=C(C(O)=C(SC=4NC=NN4)C2)C=CC=C3

Molecular Formula

C18H14N4O3S2

Molecular Weight

398.46

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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MBS5821225	Sirt1/2-IN-2
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Sirt1/2-IN-2

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