Sirt1/2-IN-4

Sirt1/2-IN-4

• CAS Number: 2999646-13-6
• UNSPSC Description: Sirt1/2-IN-4 (compound PS3) is a triple inhibitor of SIRT1/2/3 with IC50s of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (SIRT3), respsectivley. Sirt1/2-IN-4 completely blocks p53 deacetylation, with potential anti-cancer activity[1].
• Target Antigen: Apoptosis; Sirtuin
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/sirt1-2-in-4.html
• Solubility: 10 mM in DMSO
• Smiles: O=S(NC1=CC(SC2=NNC=N2)=C(C3=C1C=CC=C3)O)(C4=C(C)C(C)=C(C)C=C4)=O
• Molecular Weight: 440.54
• References & Citations: [1]Cai H, et al. Discovery of Novel SIRT1/2 Inhibitors with Effective Cytotoxicity against Human Leukemia Cells. J Chem Inf Model. 2023 Aug 14;63(15):4780-4790.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported