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Sirt1/2-IN-3

CAT: 0931-T79564-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T79564-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
301313-42-8
Target
Sirtuin, Apoptosis
Related Pathways
Apoptosis, Chromatin/Epigenetic, DNA Damage/DNA Repair
Bioactivity
Sirt1/2-IN-3 (compound PS9) serves as a dual inhibitor of SIRT1/2, exhibiting IC50 values of 1.4 μM (SIRT1) and 2.0 μM (SIRT2), respectively. This compound effectively inhibits p53 deacetylation while simultaneously elevating p53 and α-tubulin acetylation levels. Additionally, Sirt1/2-IN-3 promotes apoptosis and exhibits antiproliferative effects on human leukemia cell lines [1].
Smiles
COC1=CC=C(C=C1)S(=O)(=O)NC1=C2C=CC=CC2=C(O)C(Cl)=C1
Molecular Formula
C17H14ClNO4S
Molecular Weight
363.82
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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