Sirt1/2-IN-3

Sirt1/2-IN-3

• CAS Number: 301313-42-8
• UNSPSC Description: Sirt1/2-IN-3 (compound PS9) is a dual inhibitor of SIRT1/2 with IC50s of 1.4 μM (SIRT1) and 2.0 μM (SIRT2), respsectivley. Sirt1/2-IN-3 completely blocks p53 deacetylation, and increase of p53 and α-tubulin acetylation. Sirt1/2-IN-3 induces apoptosis and shows anti-proliferation activity against human leukemia cell lines[1].
• Target Antigen: Apoptosis; Sirtuin
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/sirt1-2-in-3.html
• Solubility: 10 mM in DMSO
• Smiles: O=S(NC1=CC(Cl)=C(C2=C1C=CC=C2)O)(C3=CC=C(OC)C=C3)=O
• Molecular Weight: 363.82
• References & Citations: [1]Cai H, et al. Discovery of Novel SIRT1/2 Inhibitors with Effective Cytotoxicity against Human Leukemia Cells. J Chem Inf Model. 2023 Aug 14;63(15):4780-4790.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported