SIRT1/2/3-IN-2

SIRT1/2/3-IN-2

• CAS Number: 388086-13-3
• UNSPSC Description: SIRT1/2/3-IN-2 (compound 9) is a potent SIRT inhibitor, with inhibition rates of 27%, 72%, and 71% targeting SIRT1, SIRT2, and SIRT3, respectively, at 200 μM. SIRT3 is a potential tumor suppressor or promoter, and its increased transcription may be associated with lymph node-positive breast cancer and oral squamous cell carcinoma[1].
• Target Antigen: Sirtuin
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/sirt1-2-3-in-2.html
• Smiles: ClC1=C(C2=NC3=CC(NC(CC4=CC=CC=C4)=O)=CC=C3O2)C=CC(Cl)=C1
• Molecular Weight: 397.25
• References & Citations: [1]Salo HS, et al. Identification of novel SIRT3 inhibitor scaffolds by virtual screening. Bioorg Med Chem Lett. 2013 May 15;23(10):2990-5.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported