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SCAL-266

CAT: 0931-T79477-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T79477-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2798953-78-1
Target
OXPHOS, Mitochondrial Metabolism
Related Pathways
Metabolism, Apoptosis
Bioactivity
SCAL-266, a potent inhibitor of mitochondrial complex I (CI), exhibits an IC50 of 0.83 μM. This compound impairs mitochondrial function by blocking oxidative phosphorylation (OXPHOS), inhibiting oxygen consumption rate (OCR), increasing reactive oxygen species (ROS) production, and diminishing mitochondrial membrane potential (MMP) . Furthermore, SCAL-266 demonstrates significant antiproliferative activity against OXPHOS-dependent cancer cells [1].
Smiles
C(C=1C=C(C=CC1)N2CCN(C(=O)C3CC3)CC2)N4N=C(C(NC5=CC=C(C(F)(F)F)C=C5)=O)C=C4C
Molecular Formula
C27H28F3N5O2
Molecular Weight
511.54
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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