SCAL-266

• Target:

  OXPHOS|||Mitochondrial Metabolism

• Related Pathways:

  Metabolism|||Apoptosis

• Bioactivity:

  SCAL-266, a potent inhibitor of mitochondrial complex I (CI), exhibits an IC50 of 0.83 ?M. This compound impairs mitochondrial function by blocking oxidative phosphorylation (OXPHOS), inhibiting oxygen consumption rate (OCR), increasing reactive oxygen species (ROS) production, and diminishing mitochondrial membrane potential (MMP) . Furthermore, SCAL-266 demonstrates significant antiproliferative activity against OXPHOS-dependent cancer cells [1].

• Smiles:

  C(C=1C=C(C=CC1)N2CCN(C(=O)C3CC3)CC2)N4N=C(C(NC5=CC=C(C(F)(F)F)C=C5)=O)C=C4C

• Molecular Formula:

  C27H28F3N5O2

• Molecular Weight:

  511.54

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2798953-78-1