SCAL-255

CAT: 0804-HY-155554-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-155554-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
SCAL-255 is a potent mitochondrial complex I (CI) inhibitor with an IC50 of 1.14 μM. SCAL-255 blocks mitochondrial function, inhibits oxygen consumption rate (OCR), induces reactive oxygen species (ROS) production, and reduces MMP. SCAL-255 can be used in the research of oxidative phosphorylation (OXPHOS) -dependent cancers, such as colorectal cancer (CRC) and acute myeloid leukemia (AML), etc[1].
CAS Number
[2798953-61-2]
UNSPSC
12352005
Target
Mitochondrial Metabolism; MMP; Oxidative Phosphorylation; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/scal-255.html
Purity
99.15
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=NN(CC2=CC=CC(N3CCN(C(C4CC4)=O)CC3)=C2)C(C)=C1)NC5=CC=C(OC(F)(F)F)C=C5
Molecular Formula
C27H28F3N5O3
Molecular Weight
527.54
References & Citations
[1]Yang Zhou, et al. Synthesis and biological evaluation of novel pyrazole amides as potent mitochondrial complex I inhibitors. Eur J Med Chem. 2023 Oct 5;258:115576.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-155555SCAL-266
HY-155888-01IV-255
HY-168674Antibacterial agent 255
HY-W953714CRBN ligand-255
HY-123715Anticancer agent 255
HY-113619AABT-255 (hydrochloride)
HY-113619ABT-255 (free base)
HY-122699LN-1-255 (sodium)
HY-P4933Tau Peptide (255-314) (Repeat 2 Domain) (human)
HY-161853-01TX-2552

Alternative Products

CatalogName
MBS5821138SCAL-255
E2378-01Scal
MF-0147132-01SCAL-266
MBS5779161ABT-255
MBS5819869IV-255
RM-T030955-01Ticagrelor Impurity 255
RM-E131855-01Empagliflozin Impurity 255
RM-S041555-01Sildenafil Impurity 255
RM-A162655-01Apixaban Impurity 255
RM-T140855-01Tenofovir Impurity 255

Popular Products