EGFR-IN-2

• Description :

  EGFR-IN-2 is a a noncovalent, irreversible, mutant-selective second generation EGFR inhibitor.

• CAS Number :

  [1643497-70-4]

• UNSPSC :

  12352005

• Target :

  EGFR

• Type :

  Reference compound

• Related Pathways :

  JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/EGFR-IN-2.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=S(N(N=C1)C=C1C2=NC=CC(NC3=NC=C(C(N4CC(C(C)(O)C)C4)=NN5[C@H](CC)C)C5=C3)=N2)(C6CC6)=O

• Molecular Formula :

  C26H33N9O3S

• Molecular Weight :

  551.66

• References & Citations :

  [1]Chan BK, et al. Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor. J Med Chem. 2016 Oct 13;59 (19) :9080-9093.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported