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JAK/HDAC-IN-4

CAT: 0931-T201233-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T201233-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
JAK, HDAC
Related Pathways
Stem Cells, Chromatin/Epigenetic, JAK/STAT signaling, Tyrosine Kinase/Adaptors, Angiogenesis, DNA Damage/DNA Repair
Bioactivity
JAK/HDAC-IN-4 (compound 11 i) is a dual inhibitor targeting both JAK2 and HDAC6, with IC50 values of 0.49 nM and 12 nM respectively. It inhibits cell proliferation and the production of nitric oxide. In a mouse model induced by Imiquimod, JAK/HDAC-IN-4 ameliorates psoriasiform skin lesions with low toxicity.
Smiles
C(/C=C/C1=CC=C(I)C=C1)(=O)C2=CC=C(B(O)O)C=C2
Molecular Formula
C30H32N8O5S
Molecular Weight
616.69
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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HY-169290JAK/HDAC-IN-4
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MBS387770-01JAK/HDAC-IN-1
GTR19230993-01JAK/HDAC-IN-2
A13362-5JAK/HDAC-IN-1 5mg
A13362-50JAK/HDAC-IN-1 50mg
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A13362-100JAK/HDAC-IN-1 100mg
A13362-10JAK/HDAC-IN-1 10mg
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