TIP48/49-IN-1

CAT: 0931-T206371-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T206371-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1807337-58-1

Target

Proton pump

Related Pathways

Membrane transporter/Ion channel

Bioactivity

TIP48/49-IN-1 (Compound B) is an orally active, specific RUVBL1/2 ATPase inhibitor, with an IC50 of 59 nM for purified RUVBL1/2. It disrupts the DNA replication process, causing S phase arrest, induces apoptosis, inhibits tumor growth, and enhances the radiosensitivity of non-small cell lung cancer cells (NSCLC) .

Smiles

O(CC)C1=C(C=2OC(=NN2)[C@@H]3C[C@H](C(NC=4C(=O)N(N(C)C4C)C5=CC=CC=C5)=O)CCC3)C=C(Cl)C=C1

Molecular Formula

C28H30ClN5O4

Molecular Weight

536.022

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Alternative Products

Catalog	Name
GTR19259534-01	TIP48/49-IN-1
E0256-01	Echistatin (1-49)
sc-136299	Pinch-1 (49)
GTR19197755-01	DK-1-49
M40688	Β-Amyloid (1-49)
GTR18904228-01	Osteocalcin (1-49)
513881	RUVBL2 (INO80J, TIP48, TIP49B) discontinued
5-01659	Osteocalcin (1-49) (human)
5-00430	beta-Amyloid (1-49)
E0256-01A	Echistatin (1-49) (FITC)

TIP48/49-IN-1

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