TIP48/49-IN-1

• CAS Number :

  1807337-58-1

• Target :

  Proton pump

• Related Pathways :

  Membrane transporter/Ion channel

• Bioactivity :

  TIP48/49-IN-1 (Compound B) is an orally active, specific RUVBL1/2 ATPase inhibitor, with an IC50 of 59 nM for purified RUVBL1/2. It disrupts the DNA replication process, causing S phase arrest, induces apoptosis, inhibits tumor growth, and enhances the radiosensitivity of non-small cell lung cancer cells (NSCLC) .

• Smiles :

  O(CC)C1=C(C=2OC(=NN2)[C@@H]3C[C@H](C(NC=4C(=O)N(N(C)C4C)C5=CC=CC=C5)=O)CCC3)C=C(Cl)C=C1

• Molecular Formula :

  C28H30ClN5O4

• Molecular Weight :

  536.022

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C