TIP48/49-IN-1

• Target:

  Proton pump

• Related Pathways:

  Membrane transporter/Ion channel

• Bioactivity:

  TIP48/49-IN-1 (Compound B) is an orally active, specific RUVBL1/2 ATPase inhibitor, with an IC50 of 59 nM for purified RUVBL1/2. It disrupts the DNA replication process, causing S phase arrest, induces apoptosis, inhibits tumor growth, and enhances the radiosensitivity of non-small cell lung cancer cells (NSCLC) .

• Smiles:

  O (CC) C1=C (C=2OC (=NN2) [C@@H]3C[C@H] (C (NC=4C (=O) N (N (C) C4C) C5=CC=CC=C5) =O) CCC3) C=C (Cl) C=C1

• Molecular Formula:

  C28H30ClN5O4

• Molecular Weight:

  536.022

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1807337-58-1