XY-06-007

• Target:

  PROTACs|||Epigenetic Reader Domain|||Others

• Related Pathways:

  Others|||PROTAC|||Chromatin/Epigenetic

• Bioactivity:

  XY-06-007, a potent and selective bump-and-hole (B&H) PROTAC BRD4 BD1 L94V degrader, exhibits a DC50, 6 h of 10 nM specifically against BRD4 BD1 L94V without degrading off-targets. It also demonstrates favorable pharmacokinetics for in vivo studies [1].

• Smiles:

  [H][C@]1(N=C(c2ccc(Cl)cc2)c2cc(OC)ccc2-n2c(C)nnc12)[C@@H](C)C(=O)NCCCCCNC(=O)COc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12

• Molecular Formula:

  C41H41ClN8O8

• Molecular Weight:

  809.27

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2757045-94-4