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PROTAC BRD4 Degrader-11

CAT: 0931-T74124-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T74124-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
Others, Epigenetic Reader Domain, PROTACs, PROTAC-Linker Conjugates for PAC
Related Pathways
PROTAC, Antibody-drug Conjugate/ADC Related, Others, Chromatin/Epigenetic
Bioactivity
PROTAC BRD4 Degrader-11 (compound 9a), a PROTAC linked through ligands to von Hippel-Lindau and BRD4, effectively targets and degrades the BRD4 protein in PC3 prostate cancer cells when conjugated with STEAP1 and CLL1 antibodies, exhibiting potent activity with DC50 values of 0.23 nM and 0.38 nM for the respective conjugations [1].
Molecular Formula
C61H75F2N9O12S4
Molecular Weight
1292.56
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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