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Abemaciclib metabolite M18

CAT: 0931-T73909-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T73909-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2704316-81-2
Target
Ligands for Target Protein for PROTAC, CDK
Related Pathways
PROTAC, Cell Cycle/Checkpoint
Bioactivity
Abemaciclib metabolite M18 (LSN3106729) is a potent cyclin-dependent kinase (CDK) inhibitor with antitumor properties. It has been incorporated alongside a cereblon (CRBN) ligand to develop a proteolysis-targeting chimera (PROTAC) that selectively degrades CDK4/6 [1] [2].
Smiles
C(C)(C)N1C=2C(N=C1CO)=C(F)C=C(C2)C3=NC(NC4=CC=C(CN5CCNCC5)C=N4)=NC=C3F
Molecular Formula
C25H28F2N8O
Molecular Weight
494.54
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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