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Abemaciclib metabolite M2 (Standard)

CAT: 0804-HY-128669R-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-128669R-01Size:1 mg
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Description
Abemaciclib metabolite M2 (Standard) is the analytical standard of Abemaciclib metabolite M2. This product is intended for research and analytical applications. Abemaciclib metabolite M2 (LSN2839567) is a metabolite of Abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s of 1.2 and 1.3 nM, respectively. Anti-cancer activity[1][2].
CAS Number
1231930-57-6
Product Name Alternative
LSN2839567 (Standard)
UNSPSC
12352005
Target
CDK; Drug Metabolite; Reference Standards
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Smiles
CC(N1C2=CC(C3=NC(NC4=NC=C(CN5CCNCC5)C=C4)=NC=C3F)=CC(F)=C2N=C1C)C
Molecular Formula
C25H28F2N8
Molecular Weight
478.54
References & Citations
[1]Teresa Burke, et al. Abstract 2830: The major human metabolites of abemaciclib are inhibitors of CDK4 and CDK6. Cancer Research. July 2016, 76 (14) .|[2]CHMP. Assessment report Verzenios. 26 July 2018 EMA/551438/2018.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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