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Abemaciclib metabolite M2-d6

CAT: 0804-HY-128669SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-128669SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Abemaciclib metabolite M2-d6 is the deuterium labeled Abemaciclib metabolite M2. Abemaciclib metabolite M2 (LSN2839567) is a metabolite of Abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s in the range of 1-3 nM. Anti-cancer activity[1][2].
Product Name Alternative
LSN2839567-d6
UNSPSC
12352005
Target
CDK
Type
Isotope-Labeled Compounds
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
99.25
Solubility
DMSO : 2.12 mg/mL (ultrasonic)
Smiles
CC1=NC2=C(C=C(C3=C(C=NC(NC4=CC=C(C=N4)CN5CCNCC5)=N3)F)C=C2N1C(C([2H])([2H])[2H])C([2H])([2H])[2H])F
Molecular Formula
C25H22D6F2N8
Molecular Weight
484.58
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Teresa Burke, et al. Abstract 2830: The major human metabolites of abemaciclib are inhibitors of CDK4 and CDK6. Cancer Research. July 2016, 76 (14) .
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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