RI-962

CAT: 0931-T73493-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-T73493-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2763831-53-2

Target

RIP kinase

Related Pathways

Apoptosis, NF-κB

Purity

0.9939

Bioactivity

RI-962 is a potent and selective inhibitor of RIPK1 that dose-dependently protects cells from necrotic apoptosis induced by TNFα, Smac mimics, and Z-VAD-FMK by inhibiting RIPK1, RIPK3, and MLKL phosphorylation with EC50=10.0 nM~17.8 nM, and improves survival in mice in two models of inflammation.

Smiles

O=C(NC(C=1C=CC=CC1)C)C2=CN(C=3C=CC(=CC23)C=4C=CN5N=C(N=C5C4)NC(=O)C(C)C)C

Molecular Formula

C28H28N6O2

Molecular Weight

480.56

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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HY-148382-01	RI-962
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RI-962

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