RI-962

• Target:

  RIP kinase

• Related Pathways:

  Apoptosis|||NF-?B

• Purity:

  0.9939

• Bioactivity:

  RI-962 is a potent and selective inhibitor of RIPK1 that dose-dependently protects cells from necrotic apoptosis induced by TNF?, Smac mimics, and Z-VAD-FMK by inhibiting RIPK1, RIPK3, and MLKL phosphorylation with EC50=10.0 nM~17.8 nM, and improves survival in mice in two models of inflammation.

• Smiles:

  O=C(NC(C=1C=CC=CC1)C)C2=CN(C=3C=CC(=CC23)C=4C=CN5N=C(N=C5C4)NC(=O)C(C)C)C

• Molecular Formula:

  C28H28N6O2

• Molecular Weight:

  480.56

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2763831-53-2