KT2-962

• Description:

  KT2-962 is a thromboxane A2 (TXA2) receptor antagonist and potent hydroxyl radical scavenger (IC50=500 nM) . KT2-962 reduces myocardial infarct size and ventricular fibrillation. KT2-962 demonstrates cardioprotective effect in a canine ischemia/reperfusion model. KT2-962 is promising for research of myocardial ischemia-reperfusion injury and TXA2-mediated vascular diseases[1].

• UNSPSC:

  12352005

• Target:

  Prostaglandin Receptor

• Related Pathways:

  GPCR/G Protein

• Field of Research:

  Cardiovascular Disease

• Smiles:

  O=S(C1=C2C=CC(C(C)C)=CC=C2C(CCCCNS(=O)(C3=CC=C(C=C3)Cl)=O)=C1)(O[Na])=O

• Molecular Formula:

  C23H25ClNNaO5S2

• Molecular Weight:

  518.02

• References & Citations:

  [1]Ge ZD, et al. Comparison of cardioprotective efficacy of two thromboxane A2 receptor antagonists. J Cardiovasc Pharmacol. 2003 Mar;41 (3) :481-8.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• Isoform:

  TXA2/TP

• CAS Number:

  [129648-96-0]