BM-962

• Target:

  Bcl-2 Family

• Related Pathways:

  Apoptosis

• Bioactivity:

  BM-962 (Compound 31) is a potent small-molecule inhibitor with an IC50 value of 4 nM (Ki=0.8 nM) for Bcl-2 and an IC50 of 3.9 nM (Ki<1 nM) for Bcl-xL. It inhibits H1417 and H146 cell lines with IC50 values of 9 and 13 nM, respectively, and shows potential for use in cancer research.

• Smiles:

  C(O)(=O)C=1C(=C(N(C(C)C)C1C)C2=CC=C(Cl)C=C2)C3=CC(=CC=C3)N4CCN(CC4)C5=CC=C(NS(=O)(=O)C6=CC(S(C(F)(F)F)(=O)=O)=C(N[C@H](CCN7CCC(O)CC7)CSC8=CC=CC=C8)C=C6)C=C5

• Molecular Formula:

  C53H58ClF3N6O7S3

• Molecular Weight:

  1079.71

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1391107-57-5