BM-962

• Description :

  BM-962 (Compound 31) is a potent small-molecule inhibitor of Bcl-2 with an IC50 value of 4 nM (Ki=0.8 nM) and Bcl-xL with an IC50 value of 3.9 nM (Ki IC50 values of 9 and 13 nM, respectively. BM-962 is promising for research of cancers[1][2].

• CAS Number :

  [1391107-57-5]

• UNSPSC :

  12352005

• Target :

  Bcl-2 Family

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/bm-962.html

• Purity :

  99.10

• Solubility :

  DMSO : 200 mg/mL (ultrasonic)

• Smiles :

  OC(C1=C(C)N(C(C)C)C(C2=CC=C(C=C2)Cl)=C1C3=CC(N4CCN(C5=CC=C(C=C5)NS(=O)(C6=CC(S(C(F)(F)F)(=O)=O)=C(C=C6)N[C@@H](CSC7=CC=CC=C7)CCN8CCC(CC8)O)=O)CC4)=CC=C3)=O

• Molecular Formula :

  C53H58ClF3N6O7S3

• Molecular Weight :

  1079.71

• References & Citations :

  [1]Chen J, et al. Structure-based discovery of BM-957 as a potent small-molecule inhibitor of Bcl-2 and Bcl-xL capable of achieving complete tumor regression. J Med Chem. 2012 Oct 11;55 (19) :8502-14.|[2]Wang SM, et al. Bcl-2/Bcl-xL inhibitors and therapeutic methods using the same. US20120189539. 2012 July 26.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported