CDKI-83

CAT: 0931-T71287-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T71287-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1189558-88-0
Target
Others|||Apoptosis|||Bcl-2 Family|||CDK
Related Pathways
Cell Cycle/Checkpoint|||Apoptosis|||Others
Bioactivity
CDKI-83 is a potent CDK9 inhibitor. The compound shows effective anti-proliferative activity in human tumour cell lines with GI50 <1 ?M, and is capable of inducing apoptosis in A2780 human ovarian cancer cells as determined by the activated caspase-3, Annexin V/PI double staining and accumulated cells at the sub-G1 phase of cellcycle. The research results suggest that combined inhibition of CDK9 and CDK1 may result in the effective induction of apoptosis and CDKI-83 has the potential to be developed as an anti-cancer agent.
Smiles
C(#N)C=1C(=NC(NC2=CC(S(=O)(=O)N3CCOCC3)=C(C)C=C2)=NC1)C=4SC(NC)=NC4C
Molecular Formula
C21H23N7O3S2
Molecular Weight
485.58
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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