CDKI-83

• Target :

  Others|||Apoptosis|||Bcl-2 Family|||CDK

• Related Pathways :

  Cell Cycle/Checkpoint|||Apoptosis|||Others

• Bioactivity :

  CDKI-83 is a potent CDK9 inhibitor. The compound shows effective anti-proliferative activity in human tumour cell lines with GI50 <1 ?M, and is capable of inducing apoptosis in A2780 human ovarian cancer cells as determined by the activated caspase-3, Annexin V/PI double staining and accumulated cells at the sub-G1 phase of cellcycle. The research results suggest that combined inhibition of CDK9 and CDK1 may result in the effective induction of apoptosis and CDKI-83 has the potential to be developed as an anti-cancer agent.

• Smiles :

  C(#N)C=1C(=NC(NC2=CC(S(=O)(=O)N3CCOCC3)=C(C)C=C2)=NC1)C=4SC(NC)=NC4C

• Molecular Formula :

  C21H23N7O3S2

• Molecular Weight :

  485.58

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1189558-88-0