CDKI-73

• Target:

  Apoptosis|||CDK

• Related Pathways:

  Cell Cycle/Checkpoint|||Apoptosis

• Purity:

  0.9811

• Bioactivity:

  CDKI-73 is a potent CDK9 inhibitor (Ki: 4 nM) . It shows selective toxicity to CLL cells (LD50=80 nM) versus normal B cell and normal CD34+ cell (LD50>20 uM) .The inhibition of CDK9 induces apoptosis and potentiates the effect of cisplatin.

• Smiles:

  CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)S(N)(=O)=O)ncc1F

• Molecular Formula:

  C15H15FN6O2S2

• Molecular Weight:

  394.45

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1421693-22-2