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MPT0B214

CAT: 0931-T71217-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T71217-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1215208-65-3
Target
Others, Microtubule Associated, Mitochondrial Metabolism, Apoptosis, Caspase
Related Pathways
Others, Proteases/Proteasome, Metabolism, Apoptosis, Cytoskeletal Signaling
Bioactivity
MPT0B214 is a novel and potent microtubule inhibitor with potential anticancer activity. MPT0B214 inhibited tubulin polymerization through strongly binding to the tubulin's colchicine-binding site and had cytotoxic activity in a variety of human tumor cell lines. After treatment with MPT0B214, KB cells were arrested in the G2-M phase before cell death occurred, which were associated with upregulation of cyclin B1, dephosphorylation of Cdc2, phosphorylation of Cdc25C and elevated expression of the mitotic marker MPM-2. Furthermore, the compound induced apoptotic cell death through mitochondria/caspase 9-dependent pathway. Notably, several KB-derived multidrug-resistant cancer cell lines were also sensitive to MPT0B214 treatment. (PLoS One. 2013;8 (3) :e58953) .
Smiles
NC=1C2=C(N=C(C(=O)C3=CC(OC)=C(OC)C(OC)=C3)C=C2)C=CC1OC
Molecular Formula
C20H20N2O5
Molecular Weight
368.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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