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MPT0B214

CAT: 0804-HY-124083Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-124083Size:1 Each
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Description
MPT0B214 is a microtubule inhibitor that strongly binds to the colchicine binding site of tubulin, preventing tubulin polymerization. MPT0B214 induces apoptosis through a mitochondrial/caspase 9 dependent pathway and shows cytotoxicity across various human tumor cell lines. MPT0B214 can be used for cancer research[1].
CAS Number
1215208-65-3
UNSPSC
12352005
Target
Apoptosis; Caspase; Microtubule/Tubulin; Mitochondrial Metabolism
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mpt0b214.html
Smiles
O=C(C1=CC(OC)=C(C(OC)=C1)OC)C2=NC3=CC=C(C(N)=C3C=C2)OC
Molecular Formula
C20H20N2O5
Molecular Weight
368.38
References & Citations
[1]Chiang NJ, et al. A novel synthetic microtubule inhibitor, MPT0B214 exhibits antitumor activity in human tumor cells through mitochondria-dependent intrinsic pathway. PLoS One. 2013;8 (3) :e58953.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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