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MPT0B214

CAT: 0013-GTR19208169-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19208169-02Size:50 mg
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Description
MPT0B214 is a novel microtubule-targeting agent that binds the colchicine site, inhibiting tubulin polymerization and exerting potent cytotoxic effects across human cancer cell lines, including multidrug-resistant variants. It induces G2-M arrest, mitotic marker expression, and caspase-9-dependent apoptosis. This compound is a valuable research tool for investigating antimitotic mechanisms and overcoming drug resistance in oncology studies.
CAS Number
1215208-65-3
Field of Research
Cell Biology, Metabolism Research, Protein Biochemistry, Signal Transduction
Smiles
NC=1C2=C (N=C (C (=O) C3=CC (OC) =C (OC) C (OC) =C3) C=C2) C=CC1OC
Molecular Formula
C20H20N2O5
Molecular Weight
368.38
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

CID 45139825
CAS Number1215208-65-3
PubChem CID45139825
IUPAC Name(5-amino-6-methoxyquinolin-2-yl)-(3,4,5-trimethoxyphenyl)methanone
Molecular FormulaC20H20N2O5
Molecular Weight368.4
XLogP3.1
Topological Polar Surface Area92.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Heavy Atom Count27
Formal Charge0
Complexity491
SMILES
COC1=C(C2=C(C=C1)N=C(C=C2)C(=O)C3=CC(=C(C(=C3)OC)OC)OC)N
InChI
InChI=1S/C20H20N2O5/c1-24-15-8-7-13-12(18(15)21)5-6-14(22-13)19(23)11-9-16(25-2)20(27-4)17(10-11)26-3/h5-10H,21H2,1-4H3
InChIKey
HBQYPNDXFXSVNP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of CID 45139825
CAS: 1215208-65-3
CID: 45139825
Formula: C20H20N2O5
MW: 368.4
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight368.4
XLogP33.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Exact Mass368.13722174
Monoisotopic Mass368.13722174
Topological Polar Surface Area92.9 Ų
Heavy Atom Count27
Formal Charge0
Complexity491
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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