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RO-5328673

CAT: 0931-T71000-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T71000-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1310817-94-7
Target
Others
Related Pathways
Others
Bioactivity
RO-5328673 is a dual NK2/NK3 antagonist. O5328673. [ (3) H]RO5328673 bound to a single saturable site on hNK2, hNK3 and gpNK3 with high-affinity. RO5328673 acted as an insurmountable antagonist at both human and guinea-pig NK3 receptors in the [ (3) H]IP accumulation assay. In binding kinetic analyses, [ (3) H]RO5328673 had fast association and dissociation rates at hNK2 while it had a fast association rate and a remarkably slow dissociation rate at gp and hNK3. In electrophysiological recordings of gp SNpc, RO5328673 inhibited the senktide-induced potentiation of spontaneous activity of dopaminergic neurons with an insurmountable mechanism of action. RO5328673 exhibited in-vivo activity in gerbils, robustly reversing the senktide-induced locomotor activity.
Smiles
N(C(OC1=CC=C(F)C=C1)=O)(C)[C@H]2[C@@H](CN(C(=O)C3CCN(C(=O)C4(C)CC4)CC3)C2)C5=CC(Cl)=C(Cl)C=C5
Molecular Formula
C29H32Cl2FN3O4
Molecular Weight
576.49
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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