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MK-8666 Tris

CAT: 0931-T69953-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T69953-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2056254-98-7
Target
Others, GPCR
Related Pathways
GPCR/G Protein, Others, Endocrinology/Hormones
Bioactivity
MK-8666 Tris is a partial GPCR (G-protein-coupled receptor) agonist that is coordinated with the action of GPR40. GPR40, also known as free fatty acid (FFA) receptor 1 modulates fatty acid-induced insulin secretion in pancreatic beta cells and in intestinal enteroendocrine cells. Thus, MK-8666 Tris has been investigated for treatment of type 2 diabetes mellitus and has been shown to robustly lower glucose without negative effects.
Smiles
NC(CO)(CO)CO.[H][C@@]12Cc3cc(OCc4cccc(c4)-c4c(C)cc(OCCCS(C)(=O)=O)cc4C)ncc3[C@]1([H])[C@H]2C(O)=O
Molecular Formula
C33H42N2O9S
Molecular Weight
642.764
Shipping Conditions
Ice Packs
Storage Temperature
-20°C