MK-8033

CAT: 0931-MF-0093099-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0093099-01Size:1 mg
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CAS Number
1001917-37-8
Target
C-Met/HGFR
Related Pathways
Tyrosine Kinase/Adaptors
Purity
0.9716
Bioactivity
MK-8033 is a new and selective dual ATP competitive c-Met/Ron inhibitor (IC50: 1 nM Wt c-Met) .
Smiles
Cn1cc(cn1)-c1cnc2ccc3ccc(CS(=O)(=O)NCc4ccccn4)cc3c(=O)c2c1
Molecular Formula
C25H21N5O3S
Molecular Weight
471.53
Shipping Conditions
Cool pack
Storage Temperature
-20°C

1001917-37-8

PubChem
cas1001917-37-8
modify2026-05-17
descriptionc-Met Inhibitor MK8033 is an orally bioavailable inhibitor of c-Met, with potential antineoplastic activity. Upon administration, c-Met inhibitor MK8033 binds to and inhibits the autophosphorylation of the c-Met protein, which disrupts c-Met signal transduction pathways and may induce cell death in tumor cells overexpressing or expressing constitutively activated c-Met protein. In addition, MK8033 inhibits Ron (receptor originated from nantes, MST1R). c-Met protein, which is encoded by the proto-oncogene MET, is a receptor tyrosine kinase also known as hepatocyte growth factor receptor (HGFR); this protein is overexpressed or mutated in many tumor cell types and plays key roles in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis. Ron, a member of the Met family of cell surface receptor tyrosine kinases, is also overexpressed on certain tumor cell types.
synonyms
MK-80331001917-37-8MK8033350H6PBQ5QDTXSID00143002
1-(3-(1-Methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo(4,5)cyclohepta(1,2-b)pyridin-7-yl)-N-(pyridin-2-ylmethyl)methanesulfonamide
5H-Benzo(4,5)cyclohepta(1,2-b)pyridine-7-methanesulfonamide, 3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-N-(2-pyridinylmethyl)-
1-(3-(1-Methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)-N-(pyridin-2-ylmethyl)methanesulfonamide
1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide
RefChem:159215+ 15 more
PubChem LinkClick here

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