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S-8666

CAT: 0804-HY-113724Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-113724Size:1 Each
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Description
S-8666 is an orally active uricosuric antihypertensive diuretic. The S-8666 has both S- (-) - and R- (+) -isomers. The diuretic and sodium-excretion activities of it are entirely dominated by the S- (-) -isomer, while the R- (+) -isomer shows no significant activity. S-8666 relies on the organic acid transport system to be secreted through the proximal tubule. S-8666 exhibits a clear uric acid excretion-promoting activity and diuretic effect in various species (such as rats and chimpanzees) [1][2].
CAS Number
103968-87-2
UNSPSC
12352005
Target
Endogenous Metabolite
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease; Cardiovascular Disease
Smiles
O=C(C1OC2=C(C1)C=C(S(=O)(N(C)C)=O)C(Cl)=C2Cl)O
Molecular Formula
C11H11Cl2NO5S
Molecular Weight
340.18
References & Citations
[1]Higaki K, Nakano M. Stereoselective disposition of S-8666, a novel uricosuric antihypertensive diuretic, and its N-monodemethylated metabolite in a perfused rat liver preparation. Effect of protein binding on the kinetics of S-8666. Drug Metab Dispos. 1992 May-Jun;20 (3) :350-5. |[2]Yonetani Y, et al. A new uricosuric diuretic, S-8666, in rats and chimpanzees. Jpn J Pharmacol. 1987 Apr;43 (4) :389-98. doi: 10.1254/jjp.43.389. Yonetani Y, et al. A new uricosuric diuretic, S-8666, in rats and chimpanzees. Jpn J Pharmacol. 1987 Apr;43 (4) :389-98. doi: 10.1254/jjp.43.389.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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