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GDC-2394

CAT: 0931-T69745-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T69745-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2238822-07-4
Target
Others, Caspase, NOD-like Receptor (NLR), Interleukin
Related Pathways
Immunology/Inflammation, Others, Apoptosis, Proteases/Proteasome
Bioactivity
GDC-2394, an orally active, selective NLRP3 inhibitor, also targets IL-1β, exhibiting inhibitory concentrations (IC50s) of 0.4 μM (human IL-1β) and 0.1 μM (mouse IL-1β) . It effectively hampers NLRP3-induced caspase-1 activity while not affecting NLRC4-dependent inflammasome activation.
Smiles
N(C(NS(=O)(=O)C1=C2N(N=C1)C[C@H](NC)CO2)=O)C3=C4C(=CC5=C3CCC5)CCC4
Molecular Formula
C20H25N5O4S
Molecular Weight
431.51
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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