GDC-2394

• Target:

  Others|||Caspase|||NOD-like Receptor (NLR) |||Interleukin

• Related Pathways:

  Immunology/Inflammation|||Others|||Apoptosis|||Proteases/Proteasome

• Bioactivity:

  GDC-2394, an orally active, selective NLRP3 inhibitor, also targets IL-1?, exhibiting inhibitory concentrations (IC50s) of 0.4 ?M (human IL-1?) and 0.1 ?M (mouse IL-1?) . It effectively hampers NLRP3-induced caspase-1 activity while not affecting NLRC4-dependent inflammasome activation.

• Smiles:

  N (C (NS (=O) (=O) C1=C2N (N=C1) C[C@H] (NC) CO2) =O) C3=C4C (=CC5=C3CCC5) CCC4

• Molecular Formula:

  C20H25N5O4S

• Molecular Weight:

  431.51

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2238822-07-4