GDC-2394

• CAS Number :

  2238822-07-4

• Target :

  Others|||Caspase|||NOD-like Receptor (NLR) |||Interleukin

• Related Pathways :

  Immunology/Inflammation|||Others|||Apoptosis|||Proteases/Proteasome

• Bioactivity :

  GDC-2394, an orally active, selective NLRP3 inhibitor, also targets IL-1?, exhibiting inhibitory concentrations (IC50s) of 0.4 ?M (human IL-1?) and 0.1 ?M (mouse IL-1?) . It effectively hampers NLRP3-induced caspase-1 activity while not affecting NLRC4-dependent inflammasome activation.

• Smiles :

  N(C(NS(=O)(=O)C1=C2N(N=C1)C[C@H](NC)CO2)=O)C3=C4C(=CC5=C3CCC5)CCC4

• Molecular Formula :

  C20H25N5O4S

• Molecular Weight :

  431.51

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C