AM-2394

• Target :

  Glucokinase

• Related Pathways :

  Metabolism

• Purity :

  0.9962

• Bioactivity :

  AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394 (AM2394) increases the affinity of GK for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes.

• Smiles :

  CNC(=O)Nc1cc(Oc2cncc(C)c2)c(cn1)-c1ccc(OCC(C)(C)O)nc1

• Molecular Formula :

  C22H25N5O4

• Molecular Weight :

  423.46

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1442684-77-6