AM-2394

CAT: 0931-T3312-01Size: 2 mgDry Ice: NoHazardous: No
CAT#:0931-T3312-01Size:2 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1442684-77-6
Target
Glucokinase
Related Pathways
Metabolism
Purity
0.9962
Bioactivity
AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394 (AM2394) increases the affinity of GK for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes.
Smiles
CNC(=O)Nc1cc(Oc2cncc(C)c2)c(cn1)-c1ccc(OCC(C)(C)O)nc1
Molecular Formula
C22H25N5O4
Molecular Weight
423.46
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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