GDC-0134

• Target :

  JNK

• Related Pathways :

  MAPK

• Bioactivity :

  GDC-0134, a dual leucine zipper kinase (DLK) inhibitor, exhibits brain penetration properties. It inhibits DLK to prevent neuronal degeneration and block JNK activation, potentially treating amyotrophic lateral sclerosis (ALS) . It has been assessed in a phase 1 study aimed at treating ALS patients.

• Smiles :

  FC1(F)CN(C=2N=C(C=C(N2)C=3C=C(OC(F)F)C(N)=NC3)N4[C@]5(C[C@@](C4)(OC5)[H])[H])CC1

• Molecular Formula :

  C19H20F4N6O2

• Molecular Weight :

  440.4

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1637394-01-4